Project Description
Defoamer for Fermentation | Foam Control for Industrial & Pharma Bioprocess
Severe foam generation across deep submerged fermentation cells limits total working volume boundaries, diminishes oxygen transfer rates (OTR), and threatens container sterility via continuous exhaust foam out-gassing. Mitigating air entrainment without affecting microbial respiration or cell harvest parameters is an empirical requirement within modern bio-manufacturing. INVINO® offers a portfolio of block copolymers and highly emulsified compounds calibrated safe for high-solids industrial molasses processing and high-yield organic acid, antibiotic, and amino acid fermentation lines.
Our non-ionic alkylene oxide structures function strictly past specific cloud point parameters, reducing interfacial tension to collapse dynamic proteinaceous air-voids. These compounds preserve chemical inertness throughout thermal sterilization (121°C Autoclave/SIP cycles) without decomposing into byproducts that inhibit culture strain metabolic growth.
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INVINO® Fermentation System Defoamer Products
| PRODUCT CODE | TYPE | ACTIVE SOLID (%) | APPLICATION PARAMETERS | TECHNICAL FILES |
|---|---|---|---|---|
| INVINO-4000B | Non-ionic Polyether (EO/PO Block Copolymer) | 100.0 | Optimized for industrial sugarcane/beet molasses ethanol fermentation, yeast cultivation, and high-gravity fuel alcohol distilling. | DOWNLOAD |
| INVINO-103 | Alkylene Oxide Block Copolymer | 100.0 | Calibrated for pharmaceutical amino acids, MSG fermentation, glutamic acid, oxytetracycline, and generic antibiotic processing. | DOWNLOAD |
| INVINO-103B | Polyether Ester Complex Blend | 100.0 | Engineered for high-purity deep culture bio-systems, vitamin fermentation (Vitamin C, B12), and continuous citric acid tanks. | DOWNLOAD |
| INVINO-7030D | Organosilicone Emulsion | 30.0±1.0 | High-dispersion compound for standard industrial waste yeast mash, food-regulated processing, and bulk molasses distillation. | DOWNLOAD |
Fermentation Defoamer Applications
High raw-material viscous loading parameters inside bulk molasses, corn, or grain-based ethanol fermentation cells create acute bubble retention boundaries. Non-silicone polyethers execute absolute droplet penetration across viscous fluids, securing continuous foam layer reduction under high heat grids to unlock maximum bioreactor capacity factors.
Deep submerged biosyntheses of Citric acid, Amino acids (Lysine, Glutamic), Vitamins (C, B12), and Antibiotics (Penicillin, Oxytetracycline) require strict strain compatibility. 100% bio-inert, non-toxic formulations guarantee absolute cell membrane respiration. Compounds withstand 121°C SIP autoclaving pipelines without decomposing into toxic side-fractions or clogging down-stream membrane UF/RO lines.
Fermentation Defoaming: Technical FAQ
Q: Will the defoamer affect the Oxygen Transfer Rate (OTR / KLa)?
A: Excessive dosing of raw silicone oils forms an uninterrupted surface barrier layer that can lower OTR indices. Our modified alkylene oxide polyether block copolymers disperse uniformly into the fluid media, breaking surfactant-heavy air bubbles without reducing dynamic gas-liquid oxygen transfer parameters.
Q: Is the defoamer stable during high-temperature sterilization (Autoclave/SIP)?
A: Yes. Traditional low-end emulsions separate and split phase blocks under thermal shock. INVINO® high-purity block polymers are engineered molecularly to survive 121°C high-pressure steam sterilization parameters without chemical structure decomposition.
Q: Does this product affect downstream membrane filtration (UF/RO)?
A: Yes, if silicone oil or mineral oil carriers build high-affinity residues that blind filter matrices. Our polyether fluids (INVINO-103/103B) are synthesized to keep completely water-soluble paths at post-fermentation separation thresholds, avoiding ultrafiltration membrane fouling.
Q: How should I add the defoamer to the fermenter?
A: We recommend adding a structural baseline volume (approx. 20–30% of total calculated dose) into the raw substrate mash before thermal sterilization. The remaining balance should be metered automatically via peristaltic dosing pumps tied to automated foam level sensors in the reactor headbox.
Standard Protocol for Bioprocess Sample Dispatch
System Parameter Submission
Provide data tracking your specific microbial strain, operating cell temperatures, aeration limits, and downstream separation layouts.
Laboratory Evaluation via 121°C Autoclave & Strain Respiration
Our fermentation laboratory group reviews your bioprocess limits, running 121°C autoclave simulation testing and strain respiration velocity checks to compile an inert matching profile sheet.
Physical Sample Freight Dispatch
Validated laboratory trial samples are packed and shipped via premium air express lines to support real-time tank evaluation metrics.
